Fig. 1: Clustering of transcriptome from single nucleus and single cells in wild-type and Arctic mice. | Nature Communications

Fig. 1: Clustering of transcriptome from single nucleus and single cells in wild-type and Arctic mice.

From: C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

Fig. 1

a Diagrammatic representation of treatment paradigm for each of the experiments, including treatment from 4.5 to 7 months (top) and 7.5 to 10 months (bottom). b Seurat cluster identification of combined cells/nuclei transcriptome. c Seurat cluster identification of cells derived from single cells (SC) or single nucleus (SN) sequencing. d Proportion of cells in each cluster originating from SC or SN transcriptome. e Proportion of cells in each cluster by treatment/genotype. f Expression of complement pathway components, receptors or regulators by cell type.

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