Fig. 2: Single cell and single nucleus RNA-Seq clustered by cell type reveals cell-specific complement gene expression. | Nature Communications

Fig. 2: Single cell and single nucleus RNA-Seq clustered by cell type reveals cell-specific complement gene expression.

From: C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

Fig. 2

Microglia or nuclei were isolated from hippocampi, fixed, and sequenced. a U-Map of all cell types with all treatment groups included (counts per cell type were: Neurons 37512, Astrocytes 4612, Oligodendrocytes 3478, Microglia 4891, OPCs 1259, Endothelial 898, Mixed 1017, Pericytes 490). b Proportion of isolated cell types in the single nucleus (SN) RNA-seq by genotype and treatment group. c Differential cell type-specific expression of complement pathway components and regulators of the complement system derived from single nucleus RNA-seq.

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