Fig. 3: DAM1 gene expression is suppressed in Arctic-PMX205 hippocampal microglia. | Nature Communications

Fig. 3: DAM1 gene expression is suppressed in Arctic-PMX205 hippocampal microglia.

From: C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

Fig. 3

a Cells/nuclei identified as microglia were re-clustered separately. b Proportion of microglia (SC + SN) clusters in WT-Veh, WT-PMX, Arc-Veh, and Arc-PMX samples. c Proportion of cells in each cluster originating from SC or SN transcriptome. d Proportion of cells/nuclei in each cluster by treatment/genotype. e Relative expression of genes representative of homeostatic microglia, DAM1, DAM2, or other genes of interest within the different microglial clusters. f Pie chart demonstrating proportion of SC microglia samples derived from different treatment groups. g Relative expression of homeostatic, DAM1, or DAM2 genes in different treatment groups, with SC data alone.

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