Fig. 6: PMX205 does not prevent all glial responses to injury. | Nature Communications

Fig. 6: PMX205 does not prevent all glial responses to injury.

From: C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

Fig. 6

Representative images of dorsal hippocampus stained for CD11b (A, left)and CD11c (a right) and Iba1 (b) in Arc-veh (top panel) and Arc-PMX (bottom panel) 10X magnification, scale bar 200 μm. c–e Quantification of percent field area (FA %) of WT-veh, WT-PMX, Arc-veh, and Arc-PMX for CD11b (c), CD11c (d), and Iba1 (e). f Representative images of dorsal hippocampus stained for S100a6 (left), LCN2 (middle), and GFAP (right) in Arc-veh (top panel) and Arc-PMX (bottom panel) 10X magnification, scale bar 200 μm. Quantification of FA% of WT-veh, Arc-veh, and Arc-PMX for S100a6 (g), LCN2 (h), and GFAP (i). Males (circles) and females (triangles) are designated in all graphs. Data shown as mean ± SEM of 3-4 images per mouse. Two-way ANOVA, n = 3-8 mice/genotype/treatment (CD11b, n = 6 WT-veh, n = 6 WT-PMX, n = 7 Arc-veh, n = 8 Arc-PMX. CD11c, n = 6 WT-veh, n = 6 WT-PMX, n = 7 Arc-veh, n = 7 Arc-PMX. Iba1, n = 6 WT-veh, n = 5 WT-PMX, n = 7 Arc-veh, n = 7 Arc-PMX. S1006a n = 3 WT-veh, n = 3 WT-PMX, n = 8 Arc-veh, n = 5 Arc-PMX. LCN2 n = 3 WT-veh, n = 3 WT-PMX, n = 7 Arc-veh, n = 5 Arc-PMX. GFAP n = 3 WT-veh, n = 3 WT-PMX, n = 7 Arc-veh, n = 5 Arc-PMX.).

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