Fig. 8: mTEC are a novel source of IL-4 in the thymus.
From: Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling
a UMAP visualization of DC and macrophage subsets colored by cell types (left). Density and feature UMAP representation of Il4 expression in DC and macrophage subsets (right). b UMAP visualization of TEC subsets colored by cell types (left). Il4 expression projected on UMAP visualization of TEC subsets (right). c Relative expression of Il4 in thymic NKT (n = 6), mTEClo (n = 9), and mTEChi (n = 9) from WT mice. Data are pooled from two independent experiments. d Confocal images of the thymus of 4get C57BL/6 mice showing IL-4eGFP (green), keratin 14 (red), and NK1.1 (blue) staining. Scale bar, 20 µm. Image representative of 3 mice. Error bars show mean ± SEM, **p < 0.01 using Kruskal–Wallis test for (c). Source data are provided as a Source Data File.
