Table 1 Aerosol and physical characteristics of three spray-dried powder formulations
|  | 1 – lead | 1 – repeat run | 2 | 3 |
|---|---|---|---|---|
Delivered dose (mg) | 26.82 | 25.6 | -- | 26.32 |
Delivered dose (% of 30 mg) | 88% | 85% | -- | 86% |
MMAD (μm) | 2.4 | 2.3 | -- | 2.5 |
GSD | 1.7 | -- | -- | 1.6 |
FPF < 5.0μm | 94% | 95% | -- | 94% |
FPF < 3.3μm | 73% | 76% | -- | 74% |
gPSD, 4 bar (μm) D10/D50/D90 | 0.487/1.40/3.02 | -- | 0.602/1.35/2.74 | 0.459/1.38/3.00 |
DSC Tg (Tg1/Tg2) | 40.8 C/124.7 C | -- | 43.1 C/121.3 C | 39.6 C/No data |
Bulk density (g/cc) | 0.26 | -- | 0.28 | 0.19 |
Water activity | 0.082 | -- | 0.079 | 0.094 |
Moisture (KF) | 1.48% | 1.48% | 1.38% | 1.46% |
Viability (CFU/g) | 3.8 × 109 | 4.6 × 109 | -- | 1.7 × 109 |
