Fig. 1: Classic and state-of-the-art strategies for ketone synthesis from primary alcohol and alkene.
From: Direct ketone synthesis from primary alcohols and alkenes enabled by a dual photo/cobalt catalysis
A Classic method for convergent ketone construction from primary alcohol and alkene. B Transition metal-catalyzed ketone synthesis from primary alcohol and alkene via dehydrogenative activation of primary alcohol. C Photocatalytic HAT enabled coupling of primary alcohols with activated alkenes to form high alcohols and dehydrogenation of secondary alcohols to form ketones. D Design of this work: a dual photo/cobalt-catalyzed hydrogen atom transfer enabled ketone assembly from primary alcohol and alkene via secondary alcohol intermediate.
