Fig. 8: The effects of lactate on B cells from young individuals, as well as on those from elderly individuals, are decreased by inhibition of the lactate transporter.
From: Immunometabolic effects of lactate on humoral immunity in healthy individuals of different ages
B cells from young and elderly individuals, isolated as in Fig. 1, were stimulated overnight with CpG (5 µg/106 cells). B cells from young individuals were stimulated with CpG in the presence of lactate (10 mM/106 cells) and secretion of IL-6, TNF-α and autoimmune IgG was measured in cultures of B cells from young individuals+lactate (a–c) or in those from elderly (d–f) individuals. Results show mean ± SE. Source data are provided as a Source Data file. Mean comparisons between groups were performed by paired Student’s t test (two-tailed). *p < 0.05, **p < 0.001, ****p < 0.0001.
