Fig. 4: Drug responses of PDGCs with different subtypes.
From: Multi-omics and pharmacological characterization of patient-derived glioma cell lines
a Schematic diagram showing the drug screening process. b Heatmap showing the drug response of PDGCs with different subtypes. The rows represent drugs, and the columns represent cell lines, colored according to the cell viability upon the treatment of corresponding drugs. The boxplots on the left side show the response of cell lines to specific drug treatments. c Drug (n = 118) response of PDGCs with different subtypes. P-values were calculated by a two-sided Wilcoxon rank-sum exact test. d, e Normalized cell viability of PDGCs with different subtypes upon treatment with the indicated drugs. Representative drugs that effectively inhibited the growth of PN and OXPHOS subtype PDGCs are listed in (d) and (e), respectively. MES (n = 26), PN (n = 30), OXPHOS (n = 26). P-values were calculated by a two-sided Wilcoxon rank-sum exact test. In b–e, boxplots show the median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). Source data are provided as a Source Data file.
