Fig. 8: Multi-layered regulation of DIM2-mediated DNA methylation.
From: Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation
A working model for the multi-layered regulation of DNA methylation by DIM2. The binding of HP1 induces a disorder-to-order transition of the DIM2 TRD. The dual readout of histone H3K9me3 by the DIM2 RFTS and BAH1 domains allosterically activates DIM2-mediated DNA methylation within the nucleosome environment. NCP nucleosome core particle. It remains to be investigated whether the two H3K9me3 marks arise from two adjacent nucleosomes or from the same nucleosome.
