Fig. 6: Variant phasing enables measurement of allelic imbalance at the single-cell level.
From: Single-cell long-read targeted sequencing reveals transcriptional variation in ovarian cancer
a Phased (H1—blue, H2—green) single-molecule read tracks for HLA-DRA. b Allelic expression (H1/H2) and proportions of cells detected for epithelial and non-epithelial groups ranked by magnitude of imbalance. c, d Plots for HLA-DRA and VEGFA, respectively: UMAP visualization of haplotype expression with epithelial cells highlighted in red and non-epithelial cells highlighted in blue. Violin plots show significant cell-type-specific allelic imbalance (two-sided Mann–Whitney U test). Source data are provided as a Source Data file.
