Fig. 2: EI-52 activity is mechanistically distinctive and tumor-type agnostic.
From: Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death
A Waterfall plot of IC50 values of 301 cell lines of the OncoPanel™ collection. Each bar represents one cell line, colored by relative drug response. B Classification of the response to EI-52 according to the origin of the cancer cell lines. Pie charts showing the distribution of cell lines classified as sensitive (red), relatively insensitive (blue), or intermediate (gray) within each cancer type represented in OncoPanel™. The number of cell lines for each tissue/tumor type is indicated in parentheses. C Dendrogram with EI-52 and 63 anti-tumor reference compounds clustered by drug sensitivity in 301 cell lines. Source data are provided as a Source Data file.
