Fig. 7: Cluster marker enrichment for human genetic limb reduction disorders and thalidomide embryopathy genes. | Nature Communications

Fig. 7: Cluster marker enrichment for human genetic limb reduction disorders and thalidomide embryopathy genes.

From: Limb reduction in an Esco2 cohesinopathy mouse model is mediated by p53-dependent apoptosis and vascular disruption

Fig. 7

Heatmap of -log10FDR. Each row represents a single cell cluster, and each column represents a gene list associated with downregulated genes that cause genetic limb reduction disorders (GLRD), and upregulated (THALU) or downregulated (THALD) genes associated with thalidomide exposure. Significantly enriched clusters are asterisked (p ≤ 0.05). P-values for enrichment were determined with a one-sided Fisher’s exact test, with Bonferroni correction for multiple testing.

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