Fig. 4: Plasmid types and transmission of plasmid carrying blaCTX-M-15.
A Bar plot showing the number of plasmid genomes and replicon types detected in the eight isolates harboring the gene blaCTX-M-15. B Timeline of transmission of plasmids encoding blaCTX-M-15 between isolates. Horizontal lines connecting circles show the mash distances between plasmid genomes in each linked group. In group 1, both isolates are from ST307/CG307. In group 2, the black asterisk (*) on pKBP97_3 indicates that the plasmid came from an ST429/CG429, while the other two isolates are members of ST307/CG307. For both panels A and B, circles are colored by clinical source (red for blood, yellow for urine). C Structural comparison of plasmid genomes encoding blaCTX-M-15 and belonging to group 1 and group 2 in panel 2B. Gray areas between plasmids represent regions with 80–100% sequence identity. Genes are represented by arrows and are color-coded according to general function: magenta—antimicrobial resistance, brown—heavy metal resistance, green—conjugation transfer, yellow—mobile elements such as insertion sequences, transposons and integrases.
