Fig. 2: Structures of human NCC complexed with indapamide, chlorthalidone, and hydrochlorothiazide. | Nature Communications

Fig. 2: Structures of human NCC complexed with indapamide, chlorthalidone, and hydrochlorothiazide.

From: Structural bases for Na+-Cl− cotransporter inhibition by thiazide diuretic drugs and activation by kinases

Fig. 2

a, b Overall structure of NCC bound with indapamide shown in map (a) and ribbon diagram (b). c, d overall structure of NCC bound with chlorthalidone shown in map (c) and ribbon diagram (d). e, f Overall structure of NCC bound with hydrochlorothiazide shown in map (e) and ribbon diagram (f). Two NCC subunits are colored-coded blue and khaki. ATP, phosphoacceptors, indapamide, hydrochlorothiazide, and chlorthalidone are highlighted. The N-terminal phosphoregulatory region is shown in cyan with the phosphorylation sites highlighted in red.

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