Table 3 Overview of validation results in the FinnGen cohort (N = 277,252)

From: Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories

 

MDD-related cluster membership

 

Cluster 1

Cluster 2

Cluster 3

Cluster 4

Cluster 5

Cluster 6

Cluster 7

Significant SNPs in the FinnGen cohorta

221

128

0

9

0

0

6

Significant loci in the FinnGen cohorta

9

4

0

1

0

0

1

Significant genes in the FinnGen cohortb

75

17

3

2

3

13

14

UKB GWAS hits available in the FinnGen cohort

1376 (72%)

1467 (75%)

1052 (72%)

1495 (78%)

1 (100%)

48 (92%)

4950 (83%)

UKB GWAS hits available and nominal significant in the FinnGen cohort

870

938

759

703

0

43

2260

…and same direction of effect (% SNPs of available UKB GWAS hits replicated)

866 (63%)

938 (64%)

759 (72%)

699 (47%)

0 (0%)

43 (90%)

2254 (46%)

Replicated locic

9 (60%)

8 (44%)

4 (29%)

6 (46%)

0 (0%)

2 (67%)

16 (44%)

Replicated genesd (% of UKB GWAS gene hits replicated)

9 (10.3%)

6 (9.7%)

1 (2%)

1 (0.9%)

0 (0%)

0 (0%)

13 (4.8%)

rg_UKB~FG

0.6521

0.5956

0.5389

0.3693

0.7652

0.8005

0.4521

  1. Association analyses were performed for each cluster using linear regression to test the association between each SNP and the posterior log odds of cluster membership, controlling for age, sex, and the first ten genetic principal components.
  2. aThe significance of SNPs refers to a genome-wide significance level of 5 × 10-8.
  3. bResults from MAGMA gene-level analyses, significance based on Holm correction, using 19,173 protein-coding genes.
  4. cNumber of replicated loci at the nominal significance level (p-value < 0.05).
  5. dNumber of replicated genes at the genome-wide significance level (Holm’s-adjusted p-value < 0.05).
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