Fig. 5: Demonstration of inclusivity and clinical use cases for the mNGS assay. | Nature Communications

Fig. 5: Demonstration of inclusivity and clinical use cases for the mNGS assay.

From: Laboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discovery

Fig. 5

A Genotyping of rhinovirus and enterovirus subtypes from PCR-positive nasal swab samples. Conventional clinical multiplex RT-PCR tests do not distinguish between rhinoviruses and enteroviruses, nor are they able to subtype more pathogenic strains such as rhinovirus C or enterovirus D68 in association with acute flaccid myelitis34,35. B Detection of uncommon or rare viral pathogens causing respiratory infections in critically ill mechanically ventilated hospitalized patients. The circles correspond to detected viruses and are color-coded by virus and scaled by read counts. For each detected virus, the read count is shown in the circle, while the identified genotype after SURPI+ pipeline is shown in the upper right quadrant. Abbreviations: ETA endotracheal aspirate.

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