Fig. 5: Chromatin loop data reveals enriched factors at relapse.

a Bar plot presenting number of loops called with Fit-Hi-C2 at diagnosis and relapse (q < 0.01). b Bar plot presenting number of loops increased, decreased or stable upon relapse (blue, red, gray respectively). c Fit-Hi-C loop correlation with gene expression and chromatin accessibility (left and right respectively). Significant differences were calculated by unpaired one-sided t test comparing genes or peaks from loops that increased or decreased to genes/peaks from stable loops (*****p < 0.00001) from relapse to diagnosis of 12 individual patient pairs. Boxplots show medians (horizontal line in each box), interquartile ranges (boxes), 1.5 interquartile (whiskers) and each point represents a gene or peak. d Enrichment analysis with LOLA of decreased and increased ATAC-seq peaks (left and right) concordant with Fit-Hi-C loops and gene expression.