Fig. 3: Substrate scope of the monoborylated gem-difluoroalkenes and coressponding Suzuki-Miyaura coupling reaction with organohalides. | Nature Communications

Fig. 3: Substrate scope of the monoborylated gem-difluoroalkenes and coressponding Suzuki-Miyaura coupling reaction with organohalides.

From: Copper-catalyzed highly switchable defluoroborylation and hydrodefluorination of 1-(trifluoromethyl)alkynes

Fig. 3

Condition B: the reaction was carried out with 1 (0.2 mmol), B2pin2 2 (2.0 equiv.), CuSCN (10 mol%), Phen (1.0 equiv.), H2O (2.0 equiv.), and MeOLi (2.0 equiv.) in CH3CN (2.0 mL) at 60 °C for 2 h under nitrogen atmosphere. aUsing CuI (10 mol%), CsF (1.5 equiv.), and the reaction was carried out at 80 °C. bCuSCN (10 mol%), tris(4-methoxyphenyl)phosphine (10 mol%), B2pin2 (4.0 equiv.), H2O (2.0 equiv.) and MeOLi (4.0 equiv.) in THF (2.0 mL) at 120 °C for 24 h. cUsing benzyl chloride instead of benzyl bromide.

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