Fig. 6: Altered chromatin accessibility at p53 associated sites.
From: Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns
A Nucleosome positioning tracks (+/−1000bp) for CTCF (top) and p53 (bottom) binding sites split by TP53-wildtype and TP53m-carrier cancer status. Increased variability and decreased central coverage are observed in TP53m-carriers at p53 binding sites. B Nucleosome positioning tracks (+/−1000bp) for the transcription start sites of housekeeping (top) and p53 target (bottom) genes split by TP53-wildtype and TP53m-carrier cancer status. Increased variability and decreased central coverage are observed in TP53m-carriers at the transcription start sites of p53 target genes. Figures show median +/− 1 standard deviation. Source data are provided as a Source Data file.
