Fig. 7: Altered chromatin accessibility at development and cancer-associated sites.
From: Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns
A Volcano of transcription factors with differential nucleosome positioning midpoints (left) and amplitudes (right) comparing cancer negative TP53m-carriers to healthy TP53-wildtype controls. p-values were calculated using Student’s two-sided t-test and corrected for multiple comparisons. B Dotplot showing changes in transcription factors with differential midpoint coverage between cancer negative and cancer positive TP53m-carriers. C Nucleosome positioning tracks showing chromatin accessibility at prostate cancer (top) and bladder cancer (bottom) associated open chromatin sites. Samples from patients with active matched cancers are also displayed in each respective plot (blue and yellow). The respective cohort medians are displayed in black +/− 1 standard deviation. D Midpoint coverage and amplitude from nucleosome positioning tracks at cancer-associated open chromatin sites from an array of LFS-associated cancer cohorts obtained from the TCGA. TP53m-carriers exhibit decreased midpoint coverage across cancer types. p-values calculated using two-sided Student’s t-test. * = p-value < 0.05, ** = p-value < 0.01, *** = p-value < 0.001. Exact p-values are provided in Supplementary Data 2. Source data are provided as a Source Data file.
