Fig. 8: Fragmentomic classification of TP53 and cancer status.
From: Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns
A ROC curves for each fragmentomic feature. Models were trained using TP53-wildtype controls and cancer-free TP53m-carriers to classify LFS from non-LFS. AUC values with 95% confidence intervals are displayed and color-matched to their respective curve. B Longitudinal integrated fragmentation scores of patients that transitioned clinically from cancer negative to cancer positive or vice versa (phenoconverter). Patient type, cancer status, cancer history, cancer stage, and cancer type are displayed. C Confusion matrix comparing the rates of cancer detection using cell-free cancer fragmentation. Clinical diagnosis was used as the ground truth. Source data are provided as a Source Data file.
