Fig. 8: NUMR-1 is a component of NoSB. | Nature Communications

Fig. 8: NUMR-1 is a component of NoSB.

From: Nucleolar stress induces nucleolar stress body formation via the NOSR-1/NUMR-1 axis in Caenorhabditis elegans

Fig. 8

A Schematic of the NUMR-1 protein structure. B DIC and fluorescence microscopy images of hypodermal nuclei after actinomycin D treatment and RNAi knockdown of exos-9 and rpl-14 in the indicated animals expressing the GFP::NUMR-1 (scale bar, 5 μm). The yellow arrows indicate NoSB. The images were taken by the Leica THUNDER imaging System. C Quantification of NoSB in indicated tissues with indicated treatment. Every dot indicates the percentage of cells containing NoSB in hypodermis cells (red), intestine cells (blue), germline cells (black), and oocyte cells (purple). n, the number of independent animals tested, see also Supplementary Fig. 16A–D. The horizontal line represents the median value, the lower and upper quartiles represent the 25th and 75th percentile, and the whiskers show the maximum and minimum values. Source data are provided as a Source Data file.

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