Fig. 6: Both 7g7 and 4h12 inhibited P. falciparum oocyst development in SMFA. | Nature Communications

Fig. 6: Both 7g7 and 4h12 inhibited P. falciparum oocyst development in SMFA.

From: Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria

Fig. 6

Mosquito luciferase assay demonstrated 7g7 and 4h12 were able to inhibit oocyst development in mosquito. Antibodies at 400 μg/ml were included in the mosquito blood meal. Mouse IgG1 3A4, an anti-PvDBP (P. vivax Duffy binding protein antibody)37, was used as a negative antibody control and no antibody (No Ab) as a negative control. Inhibition ability was measured by luciferase activity (RLU values) of infected mosquitoes. The graph is shown as mean ± s.d. of RLU values from 24, 30, 30 and 24 replicates for groups 7g7, 4h12, no antibody and anti-PvDBP, respectively. Statistical differences were calculated using Kruskal‒Wallis and Dunn’s multiple comparison test.

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