Table 1 Human PHD2 serum protein levels are positively correlated with metabolic syndrome related traits

From: Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Model*

Outcome variable

N

β coef.

95% CI

S.E.

P value

Linear regression

 

Body mass index, kg/m2

5439

0.356

(0.234, 0.478)

0.062

1.17E-08

 

Visceral fat area, cm2

5228

8.220

(6.085, 10.355)

1.089

5.20E-14

 

Triglyceride serum, mmol/L

5447

0.066

(0.048, 0.084)

0.009

6.33E-13

 

Fasting glucose, mmol/L

5447

0.063

(0.031, 0.095)

0.016

1.05E-04

 

HbA1c, g/dl

5019

0.009

(0.006, 0.012)

0.001

4.22E-11

 

Insulin serum, µU/ml

5446

1.127

(0.832, 1.422)

0.150

7.36E-14

Logistic regression

 

Type II diabetes

5447

1.191

(1.094, 1.297)

0.052

5.76E-05

 

IFG (5.6–6.9 mmol/L)

4787

1.057

(0.994, 1.124)

0.033

7.53E-02

 

Metabolic syndrome

5443

1.260

(1.186, 1.340)

0.039

9.71E-14

  1. N number of individuals with outcome data, CI confidence intervals, S.E. standard error, IFG impaired fasting glucose.
  2. *Models were adjusted for PHD2, age and sex. PHD2 beta coefficients for continuous outcome variables are from a linear regression. For dichotomous outcome variables the PHD2 beta coefficients are odds ratios from logistic regression (see “Methods” for more details on the summary statistics). P values are two-sided.
  3. Serum protein PHD2 levels were correlated with BMI, visceral adiposity, triglycerides, fasting glucose, HBA1C, insulin, type II diabetes and metabolic syndrome in the population-based Age, Gene/Environment Susceptibility (AGES) study.
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