Fig. 4: Temporal decoupling of different steps in the transformation reaction by artificially introducing energy barriers.
From: Controlled mechanochemical coupling of anti-junctions in DNA origami arrays
a, b Mechanisms used to engineer the energy landscape. d1 corresponds to the unmodified reference, d2 to a system with a locking unit incorporated and d3 and d4 to systems with missing central anti-junctions. c Lag times for the transformation to progress from Position 2 to Position 3 upon addition of all five trigger DNA strands in the systems shown in (b). Error bars represent the standard deviation of the Gaussian fit of the corresponding time difference histograms. For designs in which the majority of structures exhibited a time delay between the transformation at the different positions, only non-perfectly coupled structures with \(\triangle t\ne 0\,{{{\rm{s}}}}\) were considered. All plots show the mean values and standard errors of Gaussian fits to the corresponding time difference distributions. d–f Corresponding coupling histograms. The fraction of structures exhibiting full coupling (C > 0.95) is indicated by an orange bar.
