Fig. 2: Structure-activity relationships of SLC6A19 inhibitor JX98.
From: Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)
For each chemical modification the remaining transport activity (measured at 150 µM L-leucine) in the presence of 30 μM inhibitor is shown as a violin plot (n = 10, referring to individually seeded wells) with median (white dot), SD (whiskers), minimum and maximum (violin body) indicated. Better inhibitors result in lower residual activity. Green violins represent improvements, red violins undesirable modifications. Uninhibited cells and inhibition by 30 µM cinromide served as controls for the experiments. More details can be found in Table S1.
