Fig. 3: Pharmacological properties of optimized B0AT1 inhibitors.
From: Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)
Structures of the optimized inhibitors are shown above. L-Leucine transport activity was determined by FLIPR assay (closed symbols) and by radioactive L-leucine uptake assay (open symbols) in CHO-BC cells at the indicated inhibitor concentrations (n = 6, n referring to individually seeded cell culture dishes or wells). Data are shown as mean ± SD. Uninhibited cells and inhibition by 30 µM cinromide served as controls for the experiments.
