Fig. 2: Structural characterization of the Sy45 binding site.
From: Interdomain-linkers control conformational transitions in the SLC23 elevator transporter UraA
A Structure of UraA(G320P)-Sy45 complex viewed from within the membrane. Transport and scaffold domain are purple and green, respectively. Interdomain-linkers are blue. Sy45 is colored gray and CDR1, CDR2, and CDR3 are yellow, orange, and red, respectively. B View of the UraA(G320P)-Sy45 complex in the plane of the membrane on the scaffold domain showing the access of cytoplasmic water to the substrate binding site. C View of UraA(G320P) from the cytoplasmic side. Sy45 has been left out for clarity. Regions of UraA within 4 Å of CDR1, CDR2, or CDR3 are colored yellow, orange, and red, respectively.
