Fig. 3: Forest plot showing replication of NOTCH3 p.Arg1231Cys association with stroke across 61 K Pakistan Genome Resource meta-analysis.
From: NOTCH3 p.Arg1231Cys is markedly enriched in South Asians and associated with stroke
Shown is the cohort name, trait, odds ratio with 95% confidence interval, likelihood ratio test p value calculated using REGENIE26, alternate allele frequency, case count, and control count for five stroke phenotypes in the PGR 31 K discovery cohort (n = 5135 stroke cases and n = 26,602 controls) (top), and Inverse Variance Weighted (IVW) Meta-Analysis using METAL of stroke in 61 K PGR cohort, including 31 K PGR discovery cohort and 30 K PGR replication cohort (n = 160 cases and n = 30,239 controls) subset of the 44 K PGR follow-up cohort (bottom).
