Table 1 Baseline characteristics of PGR stroke case-control discovery cohorta

From: NOTCH3 p.Arg1231Cys is markedly enriched in South Asians and associated with stroke

 

Case (n = 5135)

Control (n = 26,602)

 

Case p.Arg1231Cys Carrier (n = 103)c

Case Non-Carrier (n = 4998)

 

mean/n

SD/%

mean/n

SD/%

P value

mean/n

SD/%

mean/n

SD/%

P value

Female, n (%)

2277

44.3

9330

35.1

<0.01

50

48.5

2211

44.2

0.44

Age at enrolment, years

58.9

13.1

52.8

11.4

<0.01

58.7

12.1

58.9

13.2

0.87

BMI, kg/m2

25

3.9

27.5

4.4

<0.01

24.6

3.4

24.9

3.9

0.35

Cholesterol, mg/dL

175.3

55.5

172.1

48.2

<0.01

174.8

49.1

175.3

55.7

0.94

LDL-C, mg/dL

111.1

45.8

101.2

38.2

<0.01

110.8

41.1

111.1

45.9

0.94

HDL-C mg/dL

37.8

12.7

35

10.8

<0.01

38.8

12.1

37.8

12.7

0.43

Triglyceride, mg/dL

140.3

81.8

185.7

120.1

<0.01

126.3

62.7

140.5

82.3

0.04

Glucose, mg/dL

148.7

75.5

143.4

84.9

<0.01

145.2

74.7

148.6

75.3

0.68

HbA1c, %

6.9

1.8

6.6

2

<0.01

7.3

1.9

6.9

1.9

0.15

Creatinine, mg/dL

1.2

0.8

0.9

0.5

<0.01

1.1

0.7

1.2

0.8

0.39

Tobacco or other stimulant userb, n (%)

1850

36

9242

34.7

<0.01

32

31.1

0

0

0.34

Comorbidities

          

     Hypertension, n (%)

2953

57.5

9385

35.3

<0.01

57

55.3

2879

57.6

1

     Diabetes, n (%)

1195

23.3

5766

21.7

<0.01

29

28.2

1157

23.1

0.29

     Myocardial infarction, n (%)

371

6.2

622

2.3

<0.01

5

4.9

215

4.3

0.98

Family history of

          

     Stroke, n (%)

324

6.3

0

0

<0.01

14

13.6

306

6.1

<0.01

     Hypertension, n (%)

573

11.2

4299

16.2

<0.01

15

14.6

556

11.1

0.35

     Diabetes, n (%)

349

6.8

5199

19.5

<0.01

11

10.7

334

6.7

0.16

     Sudden death, n (%)

150

2.9

569

2.1

<0.01

8

7.8

142

2.8

<0.01

  1. aShown are mean or total n and standard deviation or percentage for n = 5135 cases versus n = 26,602 controls on the left and n = 103 case p.Arg1231Cys NOTCH3 carriers versus n = 4998 case non-carriers on the right. Comparison was conducted using R and p values are shown from chi-square test for categorical variables (Fisher’s exact test if cell size was <5) and from T-test for continuous variables.
  2. bTobacco or other stimulants include cigarettes, paan (chewed betel leaf and areca nut), naswar (snuff), gutka (chewing tobacco), huqqa (water pipe), chillum (hasish pipe).
  3. cGenotypes for the p.Arg1231Cys variant were not available for n = 34.
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