Fig. 8: Model of proposed roles of patterning signals in chromosome segregation fidelity during human lineage specification. | Nature Communications

Fig. 8: Model of proposed roles of patterning signals in chromosome segregation fidelity during human lineage specification.

From: Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress

Fig. 8

In pluripotent stem cells, the WNT, BMP, and FGF pathways form part of an ATM-dependent signalling rheostat that modulates DNA replication stress during S-phase, which in turn regulates microtubule dynamics and chromosome segregation fidelity in the subsequent mitosis. WNT signalling sits at the helm of this regulatory network by protecting pluripotent stem cells from chromosome missegregation upon different sources of DNA replication stress, including by other patterning signals. The capacity of investigated extracellular signals to influence chromosome segregation fidelity is largely lost after exit from pluripotency and specification into the three germ layers following the withdrawal of ATM signalling as a first responder during DNA replication stress, but remerges during neurogenesis. In particular, we find that FGF signalling induces high levels of chromosome missegregation of neural progenitors committed to neurogenesis. Figure 8 was created with BioRender.com and released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license139.

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