Fig. 2: Age versus mean methylation in select chromatin states in mammals.
From: Fundamental equations linking methylation dynamics to maximum lifespan in mammals
a Displays the Spearman correlation between the inverse of mammalian maximum lifespan 1/L (x-axis) and the AROCM of diverse chromatin states. Each dot represents one of the 54 universal chromatin states57, with the AROCM defined per Methods. Only chromatin states with Spearman correlation exceeding 0.6 or below −0.3 with the inverse of maximum lifespan are labeled. More details are in Supplementary Data 2. The most pronounced correlation is found for CpGs in bivalent promoter 2 also bound by polycomb repressive complex 2 (BivProm2+). b Scaled Mean Methylation versus Relative Age across all samples; c Scaled Mean Methylation against Log-linear Transformed Relative Age in all samples. Black curves mark the overall trend. In panel c, a linear regression line was fitted per species. d–f Depicts AROCM calculation for BivProm2+ state in 3 species-tissue strata. Colored line segments/numbers in each panel represent: Young AROCM for age interval [0, 0.1L) in green; Old AROCM for age interval (0.1L, L) in blue; AROCM for age interval [0, L) in red. Pearson correlations and corresponding two-sided t-test p-values are reported in b–f. The sample size for each panel is reported on the x-axis label. Source data are provided as a Source Data file.
