Fig. 3: T cell-intrinsic AR signaling attenuates T cell autoreactivity. | Nature Communications

Fig. 3: T cell-intrinsic AR signaling attenuates T cell autoreactivity.

From: Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression

Fig. 3

a In vivo proliferation of CTV-labeled CD8+ T cells from 8-week-old 8.3.NOD.Arf/yCD4Cre− (filled circles) or Cre+ (open circles) male mice in the PLNs of NOD male hosts three days post-transfer. Significance was calculated using an unpaired t-test. Symbols – individual mice. Mean ± sem. Combined data from 3 experiments. b In vitro proliferation of CTV-labeled CD8+ T cells from 8-week-old 8.3.NOD.Arf/y (left) and G9C8.NOD.Arf/y (right) CD4Cre+ or Cre− male mice 72 hrs after stimulation with respective peptides. Significance was calculated using an unpaired t-test. Symbols – individual mice. Filled circles- Cre− controls, open circles – Cre+ mice. Mean ± sem. Combined data from 3 experiments. c T1D incidence in male NOD.scid recipients of T cells from 8-week-old NOD.Arf/y or NOD.Arf/yCD4Cre+ male mice. Significance was calculated using log-rank Mantel-Cox test. d Incidence of spontaneous T1D in NOD.Arf/yCD4Cre+ or − littermate males and females. Significance was calculated using log-rank Mantel-Cox test. n – number of mice.

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