Fig. 1: Overall structure of MtEfpA. | Nature Communications

Fig. 1: Overall structure of MtEfpA.

From: Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition

Fig. 1

a 3D reconstruction map of dimeric MtEfpA in sideview (top) and topview (bottom). Two MtEfpA monomers are colored purple and orange. Phospholipids are colored yellow, and cardiolipin (CDL) is in green. b Cartoon model of MtEfpA dimer shown as in (a). c Cross sectional view of MtEfpA at the level indicated as the dotted line in (b). d Structure of monomeric MtEfpA. The hinge domain (HD) TM7-8 (light blue) connects the N-terminal domain (NTD) TM1-6 (Blue) and C-terminal domain (CTD) TM9-14 (pink). The second transmembrane fragment breaks into two half helixes (2a and 2b). An amphiphilic helix (AH) between TM8 and TM9, is located on the cytoplasmic surface of the membrane. e Topology schematic of MtEfpA.

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