Fig. 4: Comparison of inward and outward facing states of MtEfpA. | Nature Communications

Fig. 4: Comparison of inward and outward facing states of MtEfpA.

From: Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition

Fig. 4

a Superimposition of inward state of MtEfpA (lightgray-gray-darkgray), predicted by AlphaFold, with outward state of MtEfpA (blue-lightblue-lightpink). b Movement of MtEfpA’s NTD and hinge domain from an inward state to an outward state. c The PE binding cavity at site C in outward state (right) is blocked by TM2a moving near TM13 in inward state (left). d The binding cavity at site B changes from inward open (left) to outward open (right). e The tunnel in inward and outward states of MtEfpA.

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