Fig. 3: The tetrabenazine-binding site of VMAT2.
From: Neurotransmitter recognition by human vesicular monoamine transporter 2
a, b Electrostatic surface representation of VMAT2tet highlighting in the inhibitor binding pocket. Side view (a) and top view (b). c, d The structural comparison between VMAT2tet (purple) and VMAT2dop (orange). Tetrabenazine and dopamine are indicated by yellow and green sticks. The helices are shown as cylinders. Top view (c) and close-up view (d). Residues that do not act on the other ligand are shown as transparent (d). e Detailed interaction between tetrabenazine and VMAT2. The inhibitor and contact residues are shown as yellow and purple sticks. f Schematic representation of tetrabenazine-binding interaction. Hydrogen bonds and salt bridge are shown as dashed lines.
