Fig. 5: Clinical trial simulations and parasite-killing rates in IEV wild-type parasites. | Nature Communications

Fig. 5: Clinical trial simulations and parasite-killing rates in IEV wild-type parasites.

From: Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data

Fig. 5

Distribution of the apparent killing rate against susceptible field isolates of P. falciparum at 24 h (upper panel) and 96 h (lower panel) from clinical trial simulations using a single dose of cabamiquine (free base) and pyronaridine (tetraphosphate); percentage in label: virtual patients exceeding a killing rate of 90% (dashed line); box: 25th to 75th percentile (interquartile range) with median (black horizontal line); whiskers: 1.5 times interquartile range below 25th or above 75th percentile, respectively; dots: values outside whiskers’ range; n = 1000 simulations for each dosing scenario.

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