Fig. 3: Substrate scope. | Nature Communications

Fig. 3: Substrate scope.

From: Nickel-catalyzed, silyl-directed, ortho-borylation of arenes via an unusual Ni(II)/Ni(IV) catalytic cycle

Fig. 3

Reaction conditions: benzylic silanes (0.2 mmol), B2(pin)2 (0.6 mmol), Ni(cod)2 (10 mol%), PMe3 (10 mol%), KHMDS (20 mmol%), THF (0.5 mL), 12 h, 80 °C. Yields refer to the combined yield of mono- and bis-borylated products, and the ratios were determined after purification. a Primary benzylic hydrosilanes. b Secondary & tertiary benzylic hydrosilanes. c Borylation of substrates relevant to medicinal chemistry. aBenzylsilylboronate was obtained in 15% yield. bwith Ni(OTf)2.

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