Fig. 1: ‘Large batch’ SWNTs retain their expected physicochemical properties and induce phagocytosis in vitro. | Nature Communications

Fig. 1: ‘Large batch’ SWNTs retain their expected physicochemical properties and induce phagocytosis in vitro.

From: Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis

Fig. 1

Physicochemical characterization of large-batch SHP1i-loaded SWNTs displays successful SHP1i loading and release in acidic solutions. a DLS; b UV-Vis spectroscopy; and c FT-IR spectroscopy of SWNT and SWNT-Cy5.5-SHP1i; d SHP1i release from SWNTs at neutral and acidic pH. Data are presented as mean values ± SD. n = 3 over independent replicates; e In vitro Incucyte phagocytosis assay demonstrates large batch SWNT-SHP1i treatment of RAW264.7 macrophages significantly increases phagocytosis of apoptotic cells compared to SWNT treatment. ****P < 0.0001 by unpaired two-tailed t-test. Data are presented as mean values ± SEM. n = 16 per group over technical replicates. Source data are provided as a Source data file.

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