Fig. 2: SWNTs are preferentially taken up by monocytes in the circulation. | Nature Communications

Fig. 2: SWNTs are preferentially taken up by monocytes in the circulation.

From: Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis

Fig. 2

SWNTs are preferentially taken up and retained in the circulation by pig blood monocytes and not lymphocytes. a Representative dot plots and gating strategy for SWNT uptake and retention by different immune cell types 7 days after injection. CD3+ cells represent T cells, CD21+ cells represent B cells, and CD8a+ cells represent a subtype of Natural killer cells. CD163+CD14−, CD163+CD14+, CD163−CD14+ cells represent different monocyte subtypes, while CD163−CD14− represent the remaining immune and non-immune cells. b Bar diagram of the percent SWNT+ cells in pig blood 7 days after SWNT or SWNT-SHP1i injection. **** indicates P < 0.0001 compared to CD3+, CD21+, CD8a+ NK subset and CD163−CD14− cells, as analyzed by one-way ANOVA. Data are presented as mean values ± SEM, n = 5 [n = 2 (SWNT), n = 3 (SWNT-SHP1i)] from 5 biologically independent replicates. Source data are provided as a Source data file.

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