Fig. 4: Genome-based tree of all cultured Methanobrevibacter.

Hierarchical clustering based on the ANI matrix, retrieved by the comparison of all cultured Methanobrevibacter (red letters) and already available genomes from isolates and MAGs (Supplementary Data S6). The M. smithii clade is indicated with a green background color; the Cand. M. intestini is shown with yellow background color. Cultures are accompanied by additional information on their source (healthy/ diseased donor, and culture conditions). Clusters representing one strain are indicated by black boxes (Supplementary Data S8). Source data are provided as a Source Data file.