Fig. 6: A single intranasal prophylactic dose of GS-441524 in AG129 mice intranasally inoculated with HPIV-3 reduces viral loads in the lung. | Nature Communications

Fig. 6: A single intranasal prophylactic dose of GS-441524 in AG129 mice intranasally inoculated with HPIV-3 reduces viral loads in the lung.

From: A robust mouse model of HPIV-3 infection and efficacy of GS-441524 against virus-induced lung pathology

Fig. 6

a Setup of the study. AG129 mice were administrated intranasally with a single dose of GS-441524 (40 µL/mouse of a 30 mg/mL solution) at 6 or 1 h pre-infection, and then intranasally inoculated with 1.5 × 106 TCID50 of HPIV-3. Lung samples were collected at day 3 p.i. to measure viral loads. b Infectious virus titers are expressed as log10 TCID50 per milligram of lung sample. LLOD presents the lower limit of detection. c HPIV-3 RNA levels are expressed as log10 TCID50 equivalent per milligram of lung sample. Data are from one experiment with five mice per group. Data were analyzed with the Kruskal–Wallis with Dunn’s multiple comparisons test. *p = 0.0390 (b), *p = 0.0392 (c), **p = 0.0060. Individual data and median values (indicated by bars) are presented in all graphs. Source data are provided as a Source Data file. a was designed with BioRender.

Back to article page