Fig. 1: Pediatric gliomas are infiltrated with a rich diverse myeloid cell population. | Nature Communications

Fig. 1: Pediatric gliomas are infiltrated with a rich diverse myeloid cell population.

From: Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function

Fig. 1

A Oncoprint summarizing single-cell tumor samples, including clinical information, immune cell proportions and genetic alterations. B UMAP of immune cells from 27 pediatric brain tumor samples (H3.3 K27M (N = 4) and G34R (N = 2) mutant gliomas, low-grade gliomas (LGG, N = 8) and ependymomas (EP, N = 13)) by scRNA-seq, with cells colored by projected tumor type. C UMAP of immune cells split by tumor entity. D Proportion of myeloid and lymphoid cells H3.3 K27M (N = 4) vs LGG (N = 8) and H3.3 K27M (N = 4) vs Ependymoma (N = 13) (* denotes adjusted p value < 0.05 and log fold change >1, permutation test; n = 10,000). E Proportions of myeloid cell types and activation states in H3.3 K27M (N = 4) vs LGG (N = 8) and H3.3 K27M (N = 4) vs Ependymoma (N = 13) (* denotes FDR adjusted p value < 0.05 and log fold change >1, permutation test; n = 10,000). F Proportions of lymphoid cell types and activation states in H3.3 K27M (N = 4) vs LGG (N = 8) and H3.3 K27M (N = 4) vs Ependymoma (N = 13) (* denotes adjusted p value < 0.05 and log fold change >1, permutation test; n = 10,000).

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