Fig. 2: H3.3 K27M HGG myeloid cells express immunosuppressive genes. | Nature Communications

Fig. 2: H3.3 K27M HGG myeloid cells express immunosuppressive genes.

From: Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function

Fig. 2

A Expression of differently expressed genes in H3.3K27M HGG microglia populations. B Enrichment (ssGSEA score) for immune gene sets in H3.3K27M HGG microglia populations (*** denotes adjusted p value < 0.0001, two-sided t test). C Differentialy expressed genes between H3.3K27M HGG and LGG microglia and macrophages. Genes with an adjusted p value < 0.05 and log2 fold change >0.5 are shown in red/blue (two-sided Wilcoxon ranked sum tets). D Expression of cytokines and immune checkpoints in H3.3K27M, Ependymoma and LGG. E Pathway analysis (MSigDB Hallmarks) for H3.3K27M microglia compared to LGG microglia. Significant pathways (adjusted p value < 0.05, GSEA Kolmogorov-Smirnov test) shown in red/blue. F Enrichment (ssGSEA score) for immune gene sets in H3.3K27M HGG and LGG microglia, macrophage and T-cell populations (*** denotes adjusted p value < 0.0001, two-sided t test).

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