Fig. 4: Mutant H3.3K27M and G34R cell interactions in the TME. | Nature Communications

Fig. 4: Mutant H3.3K27M and G34R cell interactions in the TME.

From: Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function

Fig. 4

A Heat map indicates IMC spatial analysis among cell phenotypes and their patterns of cell-cell interactions (red) or avoidance (blue) for H3.3K27M (top) and H3.3G34R (bottom) tumors, determined by pairwise scores. Only interaction/avoidance >50% (random chance) are shown. Associations should be read row-to-column. Rows represent the relationship of a cell type of interest. Columns represent the relationship of other surrounding cell types. Panel illustrating cell interactions created with BioRender.com, released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license. B Representative multichannel IMC images of myeloid cells (CD68+ ) interacting with K27M and G34R cells. C UMAP plots colored by expression of ligand or receptor pairs in H3.3K27M tumors (N = 4). Both immune and non-immune cells were used to predict ligand-receptor interactions. D Expression of ligand-receptor pairs in H3.3K27M immune cell populations.

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