Fig. 2: Association of lung cancer GWAS with smoking behaviors. | Nature Communications

Fig. 2: Association of lung cancer GWAS with smoking behaviors.

From: Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk

Fig. 2

a Genetic correlations between the lung cancer GWAS and smoking behaviors, including smoking initiation, cigarettes per day, smoking cessation, and age of initiation. Error bands represent the 95% confidence interval of the genetic correlation point estimates. b SNP heritability for the meta-analysis and conditional meta-analysis. The heritability decreases in the conditional analysis for overall lung cancer as well as both subtypes, suggesting that some portion of the heritability of lung cancer is due to smoking behavior. Error bands represent the 95% confidence interval of the SNP-heritability point estimates. c Polygenic risk scores (PRS) based on standard lung cancer GWAS (blue) perform worse in never-smokers than former or current smokers, while conditioning on smoking behavior (orange) results in similar performance. Error bands represent the 95% confidence interval of the odds ratio (OR) associated with a one standard deviation increase in PRS.

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