Fig. 4: Significant locus after conditioning on smoking behavior, 19p13.11, has pleiotropic associations with ER-negative breast cancer. | Nature Communications

Fig. 4: Significant locus after conditioning on smoking behavior, 19p13.11, has pleiotropic associations with ER-negative breast cancer.

From: Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk

Fig. 4

a Regional association plot of the 19p13.11 multi-trait analysis of GWAS (MTAG) locus. P-values are derived from the two-tailed MTAG test. The dashed line marks the threshold for genome-wide significance (P = 5 × 10–8). b Odds ratios and 95% confidence intervals for lead SNP rs61494113 in squamous cell lung carcinoma (LUSC), before and after conditioning on cigarettes per day, compared to lung adenocarcinoma, overall lung cancer, and MTAG analysis with estrogen receptor-negative (ER−) breast cancer. c ABHD8 expression varies by genotype at rs61494113 in GTEx v8 Lung tissue samples. t-test was utilized and a two-sided p-value is shown. The center box plot line represents the median (50th percentile). The box edges are the 25th and 75th percentiles (interquartile range; IQR). Whiskers extend to the smallest and largest values within 1.5 times the IQR. Source data are provided as a Source Data file. d ABHD8 eQTL t-statistic vs LUSC z-statistic; red X’s indicate the 95% credible set. Source data are provided as a Source Data file.

Back to article page