Fig. 5: Phenome-wide association study (PheWAS) of polygenic risk scores (PRS) of lung cancer and lung cancer conditioned on cigarettes per day. | Nature Communications

Fig. 5: Phenome-wide association study (PheWAS) of polygenic risk scores (PRS) of lung cancer and lung cancer conditioned on cigarettes per day.

From: Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk

Fig. 5

a PheWAS of PRS on lung cancer is mostly confounded with smoking associations. b PheWAS of the conditional meta-analysis PRS shows associations with skin cancer and metabolic traits. Association p-values were obtained from a two-sided test of the z-statistic, calculated using logistic regression. The red line in each plot indicates Bonferroni-corrected significance (P = 2.8 × 10–5).

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