Fig. 1: Activation of SKN-1 drives pathogen apathy.
From: Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy
A Graphical representation of the variations in food choice assays performed. B, C Apathy displayed by skn-1gf worms in the (B) traditional choice assay or (C) forced choice assays. The pathogen leaving response of WT worms is absent in response to the non-pathogenic strain PA14∆gacA (D) and resembles the apathy behavior of skn-1gf animals (E). Both WT and skn-1gf mutant animals display apathy for PA14 following depletion of wdr-23 by RNAi (F). Each of the food choice assays comprised of N ≥ 3 (with ≥ 150 worms per biological replicate per strain/condition) and analyzed via two-way ANOVA test; **(p < 0.01) ***(p < 0.001) ****(p < 0.0001). Individual “p” value numbers for the comparisons within each graph are placed above the respective comparison bars in the graph. Source data for all behavioral responses are provided as a Source Data file 1.
